Lipoprotein (a) & endothelial dysfunction

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Paul Saladino14m · 2022-11-25

Claims Made

52

Claims Supported

31

Support Rate

60%

Support rate

31 of 52 claims supported

31 supported21 partial / not

Claims from this content

47

Well SupportedSaturated fat can be beneficial for obese or metabolically unhealthy individuals, especially when consumed with starch and sugar.Well SupportedConsuming saturated fat may be beneficial and less negative than perceived.Well SupportedAntisense oligonucleotides (ASOs) have demonstrated safety and efficacy in Phase 1 and 2 trials and are enrolling in Phase 3 trials for Lp(a) reduction.Partially SupportedTraditional animal fats are likely a healthier choice than modern seed oils.Partially Supported

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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A diet enriched in saturated fatty acids significantly lowered LP(a) levels by 8-11% compared to an oleic acid diet.

Partially SupportedLP little A can be lowered by increasing saturated fat intake and raised by increasing polyunsaturated fatty acid intake.

Partially SupportedReducing polyunsaturated fatty acid intake and increasing saturated fat intake can lead to lower LDL levels.

Partially SupportedUp to 20% of the population has elevated Lipoprotein(a) [Lp(a)], with a common cutoff for elevation being 75 mg/dL.

Partially SupportedPharmacologic interventions targeting HDL to reduce atherosclerosis have been less successful than those targeting the apoB side of the equation.

Not SupportedCardiology may miss people by focusing only on LDL and not checking insulin resistance metrics.

Partially SupportedCardiologists often aim to lower LDL and ApoB as much as possible, sometimes recommending seed oils over saturated fats.

Partially SupportedMainstream cardiologists may recommend soybean oil because it lowers LDL cholesterol.

Partially SupportedLipoprotein(a) is associated with a higher incidence of cardiovascular disease.

Partially SupportedCardiovascular disease remains the leading cause of death, with a heart attack occurring approximately every 40 seconds in the United States, suggesting current treatments are often reactive rather than preventive.

Partially SupportedFocusing on whole foods that ancestral populations had access to is a more evolved approach to nutrition than focusing on processed foods.

Partially SupportedOxidized phospholipids on apob, measured via a Boston Heart test, provide a more accurate assessment of oxidized phospholipid burden than standard oxidized LDL tests.

Partially SupportedSome individuals with very high LPA do not experience cardiovascular events or have high calcium scores, suggesting other factors differentiate risk.

Partially SupportedLipoprotein(a) [LPA] is the number one genetically inherited lipoprotein that increases the risk of early cardiovascular disease.

Partially SupportedAdverse effects of replacing cis with trans fatty acids on LP(a) levels are only suggestive and restricted to high trans intakes in subjects with high LP(a) levels.

Partially SupportedIndividuals with elevated LP(a) should consider consulting with a cardiologist and potentially increasing their intake of butter.

Not SupportedDietary guidelines from organizations like the AHA may be outdated.

Well SupportedHighly processed food is likely not good for you.

Partially SupportedInterventions like endothelial function tests can identify current issues, allowing for proactive measures to prevent severe cardiovascular events.

Partially SupportedIndividuals with elevated Lp(a) should consider consulting Dr. Twyman.

Partially SupportedLipoprotein(a) particles have an extra protein that allows them to penetrate the endothelial glycocalyx more easily, causing damage.

Not SupportedNiacin offers only a modest 10-20% reduction in Lipoprotein(a).

Partially SupportedHigh LDL-C despite a healthy lifestyle may be partly miscalculated as Lp(a) if particle count is unavailable, making it unresponsive to nutritional interventions.

Partially SupportedIndividuals should focus on managing inflammation, insulin resistance, and oxidative stress as modifiable risk factors for high lipoprotein(a).

Partially SupportedA beneficial treatment for high lipoprotein(a) and multiple cardiovascular events may be available within one to two years.

Partially SupportedIf a person has high LDL-C despite a healthy lifestyle, part of the elevation may be due to miscalculated LPA, which cannot be lowered by nutrition.

Partially SupportedIncreased plasma linoleic acid following soybean oil intake was associated with increased Lp-PLA2 activity, related to ApoB, oxidized LDL, and impaired endothelial function.

Partially SupportedLipoprotein(a) [Lp(a)] is produced in the liver.

Partially SupportedAn experiment measuring endothelial function, Lp-PLA2, Lp(a), oxidized LDL, and brachial artery reactivity after consuming canola oil and less butter could assess if mainstream LDL discussions miss important factors.

Partially SupportedWhile some individuals can tolerate eating anything without negative health consequences, the majority of people cannot.

Partially SupportedElevated LPA*2 suggests that the LPA particle contains significant toxic waste.

Partially SupportedLipoprotein(a) is a genetically determined value that, if high, is unlikely to change significantly from baseline and is inexpensive to test.

Partially SupportedBob Harper had a heart attack due to high lipoprotein(a) levels.

Partially SupportedElevated lipoprotein(a) requires specific measurement and is not detected by traditional cholesterol panels.

Partially SupportedAntisense oligonucleotides can reduce LPA levels by approximately 95% by inhibiting the liver's production of the corkscrew protein on LDL particles.

Partially SupportedLPA acts as a scavenger molecule that removes oxidized phospholipids.

Partially SupportedWhen a lipoprotein(a) particle carrying oxidized phospholipids enters the artery intima, it triggers a significant inflammatory cascade.

Partially SupportedAntisense oligonucleotide drugs are in phase three trials to determine if they reduce cardiovascular events.

Partially SupportedOne theory suggests LPA's presence in the gene pool may be due to its role in preventing excessive bleeding in mothers during childbirth.

Partially SupportedWhen not in ketosis and consuming carbohydrates from fruit and honey, LDL levels may be lower.

Partially SupportedAdvanced lab testing, lifestyle interventions, supplementation, and pharmacology can guide biochemical issue management.

Not SupportedSoybean oil should not be consumed in large quantities.

Partially SupportedPaul Saladino had a coronary artery calcium score of zero at age 42-43 despite a family history of accelerated coronary artery disease and an LDL of 500.