Drinking coffee in the afternoon may negate its longevity benefits by disrupting sleep due to caffeine's 5-6 hour half-life.

“In fact, if you're drinking coffee in the afternoon to keep yourself awake, you may be losing out on the longevity benefits. Caffeine has a 5 to 6 hour half-life in your body. That means a cup of coffee at 3 p.m. leaves half a cup of coffee in your body at 9:00 p.m. That lingering caffeine in your system can wreck your sleep.”