Impaired glymphatic clearance leads to increased buildup of amyloid plaques and inflammatory molecules.

“if you impair glymphatic clearance by disrupting sleep or use some other method to impair glymphatic clearance, like disrupt the aquaporin-4 channel, that you get more buildup of things like amyloid plaques, things associated with dementia-like diseases, like Alzheimer's, but also more buildup of inflammatory molecules, like interleukins and TNF-alpha, generally, which make the brain more susceptible to microstrokes, and at a very low level, are probably what's relating to this thing that we call brain fog.”