In individuals who live a long time, the anterior mid-cingulate cortex (AMCC) maintains its size.

“as people age in particular between the ages of 60 and 90 there's a reduction in the size of many brain areas but the anterior mid singulate cortex in particular unless certain things are done to offset that”

“And in people that live a very long time, this area keeps its size.”

“the anterior mid singulate cortex is modifiable by experience by leaning into challenges at any stage of life... plasticity goes in the other direction too it seems that when we don't engage in challenges that the an mid singulate cortex it doesn't atrophy but it undergoes sort of a downshift in activation”

“there's a brain area that's available to everybody because everybody has it which is this anterior mid singulate cortex which is activated when people Embrace new forms of learning and challenges and it does seem to correlate with maintaining cognitive function into later age and it's ROP it's roped into excuse me neurally it is roped into it's linked up with the dopamine reward circuitry and other circuitries in a way that ties it some somewhat to this notion of the will to live”