Andrew Huberman· PhD
As you have an infection for many hours or days, the amount of IL-6 and IL-1 and tumor necrosis factor and other inflammatory cytokines is starting to increase such that the total amount in your circulation gets high enough and is communicated to the brain. And it tends to enter the brain through a particular type of tissue that's really interesting called choroid, C-H-O-R-O-I-D. Choroid is really interesting. It's kind of this fluffy tissue that sits in your ventricles. The ventricles are the spaces in your brain, and the spaces in your brain have what's called cerebral spinal fluid in them. The cerebral spinal fluid contains a number of important things, but the choroid starts releasing and responding to these cytokines, the inflammatory cytokines, and then the brain actually starts to experience all sorts of changes in terms of inflammation to neurons, your memory tends to get poor, your cognition tends to get poor.