Activation of a secondary pathway to the frontal lobe at the wrong time of day can induce depression in animals.

“It's a very high level center in the highest level of your nervous system and this is the region that is getting input from this pathway which is mostly worked out in its function by [indistinct] Tara's Lab. I know you had him on the podcast. - We didn't talk about this path. - This pathway at all right. So Dale Fernandez and [indistinct] and the folks that work with them, were able to show that this pathway doesn't just exist and get you to a weird place. But if you activate it at kind of the wrong time of day, animals can become depressed.”