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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Your Brain's Logic & Function | Dr. David Berson — Whalespan

Content›Video›Your Brain's Logic & Functio…

Your Brain's Logic & Function | Dr. David Berson

Andrew Huberman1h 53m · 2021-12-13

Claims Made

172

Claims Supported

159

Support Rate

92%

Support rate

159 of 172 claims supported

159 supported13 partial / not

Claims from this content

103

✓Well SupportedRegular blood work is essential for monitoring factors impacting immediate and long-term health.✓Well SupportedThorne supplements are considered highly stringent regarding ingredient precision and quality.✓Well SupportedAthletic Greens is a drink containing vitamins, minerals, probiotics, and adaptogens designed to meet foundational nutritional needs and aid recovery from stress.✓Well SupportedInside Tracker analyzes blood and DNA data to provide personalized nutrition, supplementation, and lifestyle recommendations for optimizing health markers.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

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Athletic Greens supports the gut microbiome, which is vital for the immune system, endocrine system, and gut-brain axis, influencing mood and neurotransmitter production.

✓Well SupportedVitamin K2 is important for calcium regulation and cardiovascular health.

✓Well SupportedUsing InsideTracker for over 10 years has provided valuable data showing a decrease in 'Inner Age'.

✓Well SupportedBright light, particularly blue light, suppresses melatonin production; high exposure during the day and minimal exposure at night is beneficial.

✓Well SupportedAndrew Huberman fasts until 11 AM or 12 PM, then consumes a low-carb, keto-ish lunch and dinner with carbohydrates to aid sleep.

✓Well SupportedVitamin D3 is important for immune system function, metabolic function, and other biological pathways.

✓Well SupportedAthletic Greens contains adaptogens, which are critical for recovering from stress.

✓Well SupportedA healthy gut microbiome is important for supporting the immune system, nervous system, and endocrine system.

✓Well SupportedIn individuals blind from birth, the visual cortex can be repurposed to process tactile information, such as for Braille reading.

✓Well SupportedBlue light from LEDs suppresses melatonin production, making the brain believe it is still daytime.

✓Well SupportedSufficient light exposure during the day is important for mood regulation and can help mitigate seasonal affective disorder.

✓Well SupportedMagic Spoon cereal contains zero grams of sugar, 13-14 grams of protein, and 4 net grams of carbohydrates per serving, with 140 calories.

✓Well SupportedAlmost every organ in the body has a clock that helps the organ perform at peak capacity during certain times of the day and rest and rejuvenate at other times.

✓Well SupportedConsuming adequate nutrients is important to avoid harm when practicing intermittent fasting.

◐Partially SupportedIpRGCs communicate day and night information to the brain.

◐Partially SupportedBright light exposure in the middle of the night can suppress melatonin levels.

◐Partially SupportedWhen blindness is caused by eye or retinal problems, the visual cortex may be repurposed by the nervous system.

◐Partially SupportedIntrinsically photosensitive retinal ganglion cells contain a photopigment that acts as the initial sensor for brightness.

◐Partially SupportedThe superior colliculus is a primary area for interpreting visual input and organizing behavioral responses.

◐Partially SupportedSeek bright light exposure, ideally from sunlight, to maximize alertness, and do the opposite to promote sleepiness.

◐Partially SupportedDamage to the cerebellum impairs coordination and motor learning but does not cause paralysis or sensory loss.

◐Partially SupportedMost humans have three cone types for color vision, while most mammals like dogs and cats have only two.

◐Partially SupportedMotion sickness results from conflicting visual and vestibular sensory input.

✕Not SupportedWearing blue-blocking glasses during the day is counterproductive as bright light is beneficial for circadian rhythm and alertness.

◐Partially SupportedThe basal ganglia are responsible for learning action sequences to achieve goals and coordinating muscles for tasks.

◐Partially SupportedThe autonomic nervous system controls breathing, heart rate, skin conductance, pupil size, and alertness/calmness via sympathetic and parasympathetic branches.

◐Partially SupportedDamage to the cerebellum results in clumsiness, poor movement coordination, disturbed gait, and difficulty with precise reaching, but not paralysis.

◐Partially SupportedParticipating in projects like Eyewire can provide individuals with experience in neuroscience research and allow them to contribute to scientific understanding.

◐Partially SupportedThere is significant variation in the quality of herbal supplements, both between companies and by herb type.

◐Partially SupportedThe chemical cascade for signal transmission from light absorption to electrical response in human photoreceptors differs from that in insects.

◐Partially SupportedThe suprachiasmatic nucleus influences the autonomic nervous system, hormonal systems, and higher brain centers that organize rational behavior.

◐Partially SupportedThe basal ganglia system implements cortical plans and influences them by providing information to the cortex.

◐Partially SupportedDifferent types of retinal ganglion cells encode distinct visual information.

◐Partially SupportedInteroception involves focusing on one's internal bodily state rather than external stimuli.

◐Partially SupportedNearly all cells in the body possess internal biological clocks that require synchronization.

◐Partially SupportedThe circadian system uses a 'daylight now' signal to adjust the internal clock and correct for discrepancies like jet lag.

◐Partially SupportedBiological clocks, like the circadian system, are not precision engineered and can drift slightly from a 24-hour cycle.

◐Partially SupportedThe superior colliculus receives input from auditory and touch systems, in addition to visual input, to process external sensory information from specific locations.

◐Partially SupportedSensory information, regardless of its origin (eyes, ears, nose, feet), is ultimately processed as electrical signals within the nervous system.

◐Partially SupportedRod cells, which use a specific pigment, are responsible for vision in very low light conditions, such as on a moonless night.

◐Partially SupportedA synchronization signal, such as the rising and setting of the sun, is necessary to confirm and align with the external day-night cycle.

◐Partially SupportedThree different proteins in the retina are responsible for color vision, each absorbing light at a preferred frequency, and the nervous system compares these signals to determine wavelength composition.

✓Well SupportedThe suprachiasmatic nucleus (SCN) in the hypothalamus acts as the central pacemaker for the body's circadian system.

◐Partially SupportedThe brain determines if a sensed movement was self-willed or externally caused by integrating vestibular signals with intended actions and other sensory information.

◐Partially SupportedThe cerebellum is involved in motor learning and refining movement precision, enabling accurate actions like reaching for an object without knocking it over.

◐Partially SupportedThe non-image-forming visual pathway influences mood and other aspects of light perception.

◐Partially SupportedThe vestibular system helps stabilize the image of the world on the retina, which is crucial for clear vision.

◐Partially SupportedThe vestibular system uses three sets of fluid-filled hoops oriented in different directions to detect head rotation along three axes.

◐Partially SupportedHigher levels of the nervous system can override automatic movements when they are inappropriate or maladaptive.

◐Partially SupportedIncreased time spent outdoors by children is correlated with a reduced incidence of myopia.

◐Partially SupportedThe falling reflex is a robust response triggered by rapid visual changes, though individual tolerance varies.

◐Partially SupportedThe ability to suppress reflexes and make deliberate choices can be improved with practice.

◐Partially SupportedThe protective effect of outdoor time against myopia in children may be related to light exposure or visual accommodation.

◐Partially SupportedModern DNA tests can provide information about how specific genes impact immediate and long-term health.

◐Partially SupportedThe biological mechanisms underlying color vision appear highly similar across individuals, suggesting a consistent physiological process on the 'front end' of perception.

◐Partially SupportedThe vestibular system may activate pleasure centers in the brain.

◐Partially SupportedIngrained knowledge and reflexes are crucial for performance when conscious processing time is insufficient.

◐Partially SupportedChildren often tolerate more intense vestibular stimulation, such as spinning, than adults.

◐Partially SupportedPhotoreceptors in the retina convert electromagnetic radiation into electrical signals.

◐Partially SupportedFlies taste things with receptors located on their feet.

◐Partially SupportedThe peri-habenular region links peripheral sensory input to the cortex for processing and planning.

◐Partially SupportedLooking at a stable image on a phone screen while in a moving vehicle creates a visual-vestibular conflict, leading to nausea.

◐Partially SupportedSpecific frequencies within the electromagnetic spectrum are detectable by neurons in the retina, leading to visual perception.

◐Partially SupportedInability to see clearly, like reading fine print, is a more significant visual limitation than colorblindness.

◐Partially SupportedThe marshmallow test demonstrates the cortex's role in inhibiting immediate gratification for long-term gain.

◐Partially SupportedActivation of a secondary pathway to the frontal lobe at the wrong time of day can induce depression in animals.

◐Partially SupportedOverthinking a well-trained motor skill can lead to errors by interfering with ingrained reflexive knowledge.

◐Partially SupportedRecognition of complex visual stimuli involves the cooperative activity of millions of neurons.

◐Partially SupportedThe visual cortex creates a spatial representation or map of the visual world.

◐Partially SupportedBi-directional communication between high-level cognitive centers and lower-level reflexive centers is necessary for nuanced behavior.

◐Partially SupportedThe chemical cascade in intrinsically photosensitive retinal ganglion cells is more similar to fly photoreceptors than mammalian ones.

◐Partially SupportedAndrew Huberman practices a daily 'no-go' protocol by attempting to refrain from reaching for his phone to test his ability to prevent reflexive engagement.

◐Partially SupportedThe brain's ability to cross-correlate weak signals from multiple sensory systems enhances the likelihood of detecting something significant.

◐Partially SupportedThe dopaminergic system's widespread distribution suggests a role in mediating pleasure from vestibular stimulation.

◐Partially SupportedThe timing and type of light exposure are critical for health.

◐Partially SupportedThe sympathetic nervous system promotes alertness, while the parasympathetic nervous system promotes calmness.

◐Partially SupportedBrain circuitry is multi-purposed, with areas capable of multitasking or having multiple functions.

◐Partially SupportedBlind individuals with retinal blindness may experience insomnia due to circadian clocks drifting out of phase without light synchronization.

◐Partially SupportedThe nervous system is aware of motion at multiple levels, including subcortical areas that process reflexes without conscious thought.

◐Partially SupportedWikipedia can be a useful starting point for understanding specific aspects of visual function.

◐Partially SupportedNeural activity during visualization of a known face may resemble activity when actually seeing that face.

◐Partially SupportedThe suprachiasmatic nucleus influences the pineal gland, a major source of melatonin, via the sympathetic nervous system.

◐Partially SupportedThe standard pathway for sensory input to the cortex involves passing through the thalamus, which then directs signals to specific cortical areas for processing.

◐Partially SupportedThe connectome aims to understand the structure of nervous tissue down to individual synapses and synaptic vesicles.

◐Partially SupportedThe cerebellum acts as an error correction system for sensory deficits.

◐Partially SupportedDifferent wavelengths of light are decoded by the nervous system to produce color.

◐Partially SupportedThe cerebellum integrates visual and vestibular information to stabilize images and learn compensatory movements.

◐Partially SupportedThe visual world is represented by dozens of maps on the surface of the cortex.

◐Partially SupportedPracticing 'no-go' behaviors, like refraining from reflexive phone use, creates a gap in consciousness for deliberate decision-making.

◐Partially SupportedA device that counts photons could be useful for monitoring light exposure, indicating if one is receiving adequate bright light during the day or excessive light at night that suppresses melatonin.

◐Partially SupportedIndividual differences in running 'go-no-go' circuits and task engagement are attributed to variations in genetics and life experiences, and the brain can be trained through learning new skills, acting differently, or showing more restraint.

◐Partially SupportedConnectomics and serial electron microscopy allow framing questions from anatomy to predict cellular interactions and probe physiology.

◐Partially SupportedThe ability to suppress reflexes is a key differentiator between humans and other animals, and is a function of the cortex.

◐Partially SupportedUnderstanding neurotransmitter release sites and target sites is essential for comprehending information flow in the brain.

◐Partially SupportedThe cortex and basal ganglia work together to control behavior, acting upon primitive reflexes.

◐Partially SupportedThe cortex adds nuance, context, past associations, and learning from others through communication to decision-making.

◐Partially SupportedVigorous shaking can sometimes calm infants.

◐Partially SupportedA specific type of photoreceptor cell in the eye can provide a brightness signal to the brain.

◐Partially SupportedOpening the Eustachian tube passageway is the primary factor for equalizing ear pressure during ascent or descent.