Andrew Huberman· PhD
I highly recommend finding a threshold of exercise that stimulates brain alertness, that triggers these pathways that are now starting to be clear, that they occur from the literature in animals and humans.
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I highly recommend finding a threshold of exercise that stimulates brain alertness, that triggers these pathways that are now starting to be clear, that they occur from the literature in animals and humans.
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Now, that enhanced opportunity for neural plasticity comes by way of two different pathways. You already heard about the first one, which is the locus coeruleus release of norepinephrine. That's going to increase alertness, which is a prerequisite for focus. And it appears to be the case that the release of acetylcholine from nucleus basalis, that's also triggered by this high-intensity exercise, is what allows for that alertness to be converted into focus, and those two things together, alertness and focus, are the triggers for adult neural plasticity.
that alertness is coming in large part by way of the release of norepinephrine from locus coeruleus, that the focus is being augmented, and perhaps, it's even originating entirely from the release of acetylcholine and nucleus basalis that acts as sort of a spotlight on a particular set of things that are happening while we're trying to learn, and then, that triggers the plasticity process, which takes place during sleep.