The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
what's interesting about guanfacine is that it has a bunch of Pathways that it activates that feed back onto the autonomic nervous system to dampen down the activation of the sympathetic nervous system so whereas most of what we talked about today are sympathomimetics they tend to make us more ramped up more aroused and alert guanfacine is doing the opposite
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the other thing about guanfacine is that because it lowers blood pressure and it has this effect of kind of dampening down overall sympathetic arousal sometimes it is prescribed in conjunction with other ADHD meds so yes there are kids out there and adults out there who are taking Adderall and guanfacine where they're taking Vyvanse and guanfacine
guanfacine is an interesting compound it's a compound that was developed to lower blood pressure and indeed it does lower blood pressure and it is an alpha 2A Agonist Alpha 2A being a receptor for norepinephrine so guanfacine is a non-stimulant medication to treat ADHD and it's also used to treat some other conditions as well that is only working on the noradrenergic system it is not tapping into the dopamine system but all the other stuff that we talked about is really ramping up dopamine and norepinephrine guanfacine is only increasing norepinephrine and it's doing so by what we say agonizing or stimulating one particular aspect of the noradrenergic system and that's the alpha 2A system