Excitation of the left dorsolateral prefrontal cortex is associated with a reduction in depressive symptoms.

“If you take lesions that cause mania in individuals and you put those all on the human connectome map and ask what the one common area they're all connected to, it's the right dorsolateral.”

“And so there seems to be a hemispheric, you know, balancing of mood between these two brain regions. And we know this from an experimental standpoint too, because you can take individuals with depression and you can excite the left or you can inhibit the right and they're both antidepressant. You can excite the right and that's anti-manic in some studies.”

“Yeah. Yeah, I think, so left dorsolateral is thought to be the side that when you excite it, when you kind of do excitatory stimulation, potentiating sort of stimulation, that you can reduce depressive symptoms. And a guy by the name of Mike Fox at Harvard demonstrated that if you have strokes in the brain that cause depression and you put them on the human connectome, a hundred, you know, thousand patient map, and you ask the question what they're all functionally connected to? Left dorsolateral.”