Studies on creatine's cognitive effects measure processing speed and memory, with benefits most pronounced under stress.

“It does seem as though that that's when creatine seems to shine in the brain.”

“Um and so the studies that typically are looking at the effects of creatine on cognitive function are looking at like processing speed. They're looking at a battery of tests that are, you know, typical of any, you know, fill-in-the-blank supplement or treatment that is either going to improve cognitive function, memory being another one, right? Um processing speed's a big one, too. I would say that that creatine's been shown to improve, but again really it's in the background of stress, whether that's stress being aging.”

“With the brain, it works in the background of stress. And what I mean by stress is sleep deprivation, psychological stress, like you have an exam, marital, I mean what whatever psychological stress, emotional stress, sleep deprivation is a big one, ner degenerative disease or anything that's compromising brain function, right? That's where creatine really shines in terms of cognitive function.”

“Processing speed is a big one, too. I would say that that creatine's been shown to improve, but again, really, it's in the background of stress, whether that's stress being aging, so older adults. So, aging is kind of a stress, right? Brain aging. So older adults seem to benefit from taking exogenous creatine or supplemental creatine.”

“It boosts ATP production to fuel your muscles, and emerging research shows it also sharpens cognitive function, especially under stress and fatigue.”

“improves cognition (especially during stress)”

“and when you look at the mental fatiguing uh studies that's when creatine seems to work after you've done a whole bunch of fatiguing exercises or sorry taken creatine before it really speeds up your ability to maintain memory and cognition”