The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
now the problem with piperine is that the reason it works to increase the absorption of curcumin is that piperine is a UDP glucocil transferase inhibitor meaning that piperine inhibits the enzyme that your liver is using to detoxify curcumin
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the reason it's getting absorbed more the reason you're getting higher plasma levels of curcumin is because you are inhibiting your body's ability to detoxify curcumin so you are inhibiting udp-glucose will transferase which is the enzyme your body uses to put a glue Quran I boya T on to curcumin to get it out of your body
the reason biochemically that piperine increases the absorption of curcumin from turmeric is because it inhibits the enzyme udp glucuronasal transferase in the liver which is a phase 2 detoxification enzyme
piperine inhibits udp glucuronical transferase which is one of the enzymes that adds a glucuronide moiety to curcumin which gets it out of the body so if you inhibit the addition of glucuronide in phase 2 detoxification in the liver to curcumin you can't get rid of it and you get 2 000 times higher doses in your body
the other thing to note again is that the oral bioavailability of curcumin without something like piperine is very very poor i see this as an indication that your body doesn't want this molecule in it and is going to detoxify it which we know is true and excrete it almost immediately