Are curcumin and sulforaphane good for you?

PS

Paul Saladino29m · 2019-03-12

Claims Made

56

Claims Supported

23

Support Rate

41%

Support rate

23 of 56 claims supported

23 supported33 partial / not

Claims from this content

46

Well SupportedAll vitamins and minerals found in plants can be obtained from animal sources in more bioavailable forms.Partially SupportedSulforaphane is released from glucoraphanin in crushed or chewed broccoli sprouts as a plant defense mechanism.Not SupportedSulforaphane is directly toxic to the thyroid gland, inhibiting iodine uptake and thyroid hormone production.Well SupportedHumans are likely facultative carnivores, meaning meat is their primary optimal food source.Not Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Cruciferous vegetables like kale and cauliflower contain goitrogens that can block iodine absorption and negatively impact thyroid function.

Well SupportedElevated TSH levels with high broccoli sprout consumption may indicate sulforaphane inhibiting thyroid hormone production.

Not SupportedPiperine in pepper inhibits liver detoxification enzymes, leading to higher concentrations of compounds like curcumin.

Partially SupportedPiperine enhances curcumin absorption by inhibiting the body's detoxification enzyme, UDP-glucuronosyltransferase (UGT).

Not SupportedCurcumin has been associated with over 120 failed randomized controlled trials and can interfere with potassium channels, DNA replication, and DNA repair enzymes.

Well SupportedNightshades, such as tomatoes, bell peppers, and chili peppers, are immunogenic and can increase gut permeability.

Well SupportedVitamin C can be obtained from animal sources like liver and brain, negating the need for it from plants.

Partially SupportedEliminating brassica vegetables from the diet can lead to improvements in gastrointestinal issues, thyroid symptoms, mood, and autoimmune symptoms for many individuals.

Well SupportedUsing long wavelength light, such as red or amber light, in the middle of the night is less likely to reduce melatonin production unless it is very bright.

Partially SupportedUsing red lights at night helps maintain melatonin production and prevents circadian disruption.

Partially SupportedFruit may not offer significant redeeming nutritional value.

Not SupportedViewing bright light between approximately 10 PM and 4 AM can suppress melatonin production and alter the circadian clock.

Not SupportedCurcumin is a supplement with no proven benefit and significant potential for harm, and should not be taken.

Partially SupportedPiperine found in pepper inhibits UDP-glucuronosyltransferase in the liver, which is involved in detoxification.

Not SupportedVitamin K2 from foods like liver and meat is sufficient for healthy teeth and bones, negating the need for fluoride in toothpaste.

Partially SupportedCrigler-Najjar syndrome and Dubin-Johnson syndrome are diseases associated with severe deficiencies or mutations in UDP-glucuronosyltransferase.

Partially SupportedPlant foods primarily work by reducing the breakdown of Nrf2 and breaking down the inhibitor Keap1, thereby upregulating the body's own antioxidant response elements.

Not SupportedThe potential harms of plant phytochemicals may outweigh their purported benefits like antioxidant effects via hormesis and Nrf2 activation.

Not SupportedResveratrol may possibly induce autoimmunity.

Not SupportedPaul Saladino avoids consuming pepper because piperine inhibits liver enzymes responsible for glucuronidation and detoxification.

Not SupportedSafrole, a plant compound found in pepper, can induce chromosomal breaks.

Not SupportedConsuming large amounts of fruit is not recommended because it can be hard on the liver, use up ATP, and increase uric acid.

Not SupportedPlant molecules and mycotoxins in grains can cause issues for people.

Partially SupportedThe Nrf2 pathway can be stimulated by plant compounds, exercise, sunlight, polycyclic aromatic hydrocarbons, and heterocyclic amines.

Not SupportedChlorogenic acid and caffeic acid, components of coffee, can induce chromosomal breaks.

Not SupportedMany plant compounds and herbs may be harmful for humans.

Partially SupportedThe paper 'Dietary Pesticides: 99.9% Natural' by Bruce Ames discusses class dougenicity on the last page.

Partially SupportedAdequate glutathione status can be achieved through a healthy lifestyle without consuming plant polyphenols.

Partially SupportedThe speaker has avoided all plant compounds for six months to understand the effects of an animal-based diet.

Partially SupportedPlant molecules, while potentially hormetic, can cause collateral damage because they are foreign to the human operating system.

Not SupportedPiperine inhibits glucuronidation, which is undesirable for detoxification.

Partially SupportedProtein is not bad for the liver or kidneys and is beneficial for human health.

Partially SupportedRed lights are used to allow normal production of melatonin by preventing blue light inhibition.

Not SupportedThe mainstream promotion of curcumin as a 'superfood' should be met with skepticism.

Partially SupportedEating turmeric with pepper leads to problematic absorption of curcumin, while eating turmeric without pepper is acceptable due to low curcumin absorption.

Partially SupportedMost essential nutrients can be obtained from food, particularly organ meats like liver, and supplementation should only be considered after micronutrient analysis if deficiencies are suspected.

Limited ResearchSafrole, found in peppercorns, is a compound of suspicion regarding supplement safety.

Not SupportedCurcumin and sulforaphane are molecules for which the speaker argues they do nothing unique and are individually harmful to humans.

Partially SupportedCurcumin is poorly absorbed (less than 1%) and immediately detoxified by the liver.

Partially SupportedThe Nrf2 pathway can be induced by various lifestyle factors, leading to endogenous glutathione production.

Partially SupportedExercise and sunlight can induce the Nrf2 pathway, contributing to robust glutathione status.

Partially SupportedThe speaker's personal data shows high glutathione, low 8-hydroxy-2'-deoxyguanosine, and low lipid peroxide levels, indicating a healthy antioxidant status without plant polyphenols.