We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
so pepper is going to inhibit UDP who karana so transferees piperine and pepper does that so the reason you get higher blood levels of curcumin when you package it with piperine is that you're inhibiting your body's ability to detoxify it
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pepper contains a compound called piperine which inhibits detoxification enzymes in the liver if you want the full name it's udp glucuronasal transfer it so pepper contains and then a compound called hyperine that's going to inhibit your phase 2 detoxification in the liver this is why compounds like curcumin which your body is actually trying to get rid of end up in much higher amounts 2 000 plus times amounts in your body when you eat pepper
grapefruit is the one citrus fruit that has a furano coumarin that can inhibit one of your p450 enzymes and inhibit detoxification in your liver
this is one reason that i am not a fan of many plant compounds that will inhibit enzymatic systems in phase 1 or phase 2 detoxification some of those are things like furano coumarins that's been the subject of many things recently like they are that are found in things like grapefruit right grapefruit is the one citrus fruit that has a furano coumarin that can inhibit one of your p450 enzymes and inhibit detoxification in your liver pepper black pepper this is another topic that's coming on my instagram feed i'm not a fan of that because it has compounds like piperine that do the same thing that inhibit udp glucuronasal transferase
black pepper this is another topic that's coming on my instagram feed i'm not a fan of that because it has compounds like piperine that do the same thing that inhibit udp glucuronasal transferase that is a glucuronide adding enzyme it adds glucuronide to toxins and then they're excreted in your poop and your feces and your urine
I don't really like black pepper or white pepper because of the way they're going to inhibit some of the detoxification enzymes in the liver like UDP glucuronacil transferase and they might irritate the gut a little bit