2022 Kick Off Ask Me Anything (AMA): Cholesterol, Skin Care, Liver, and More

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Paul Saladino39m · 2022-01-04

Claims Made

79

Claims Supported

59

Support Rate

75%

Support rate

59 of 79 claims supported

59 supported20 partial / not

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70

Well SupportedHeart & Soil supplements are freeze-dried and sourced from grass-fed, regeneratively raised animals in New Zealand.Well SupportedThe Heart & Soil histamine and immune supplement may improve allergies.Well SupportedMost people will feel better when they increase their protein intake to one gram per pound of body weight, which can also increase bone density.Well SupportedAn effective dose of liver is approximately 0.5 to 1 ounce per day, which provides significant amounts of choline, vitamin A, K2, selenium, zinc, and copper.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Hunter-gatherer groups like the Hadza prioritize animal meat, organs, blood, and fat as primary foods.

Well SupportedAnimal fats like tallow are a preferred source of nutrition and contain stearic acid, which activates mitochondrial fat burning, and odd-chain fatty acids.

Well SupportedLectins found in nightshade plants, seeds, nuts, grains, and beans can disrupt gut flora balance.

Well SupportedPaul Saladino has a coronary artery calcium scan of zero.

Well SupportedEliminating vegetables led to significant improvements in autoimmune diseases for some individuals.

Well SupportedObesity is not observed in hunter-gatherer tribes.

Well SupportedConsuming organ meats can provide an immediate feeling of well-being and energy.

Well SupportedAn ounce of liver is unlikely to cause copper overload due to the body's regulation of copper and zinc.

Well SupportedNative sugars like honey are not a significant problem when consumed in the context of a traditional hunter-gatherer diet and lifestyle.

Well SupportedA recommended daily intake of 0.5 to 1 ounce of liver, fresh or desiccated, is impactful and unlikely to cause vitamin A toxicity.

Not SupportedPiperine in pepper inhibits liver detoxification enzymes, leading to higher concentrations of compounds like curcumin.

Not SupportedSaurolin, found in celery, is associated with phytophotodermatitis and increased skin cancer risk.

Well SupportedThe supplement 'Whole Package' from Heart and Soil Supplements can lead to noticeable results within hours, including increased energy, libido, and muscle density.

Well SupportedThe optimal human diet historically consisted of meat, organs, animal fat, followed by fruit and honey, with roots, leaves, and seeds being less prioritized.

Well SupportedA carnivore diet simplifies eating by eliminating plants and may benefit individuals not thriving on other diets or who are very ill.

Well SupportedIndigenous populations like the Tsimane and Hadza historically had very low rates of cardiovascular disease, cancer, dementia, and chronic inflammatory diseases.

Well SupportedThe best approach to navigating conflicting nutritional advice is to conduct personal experiments, research independently, and determine what makes one feel best.

Partially SupportedSaturated fats from ruminants are evolutionarily consistent and healthy, while processed foods and vegetable oils containing linoleic acid are detrimental.

Partially SupportedTallow is non-comedogenic and can be applied topically to the face to help with fine lines and wrinkles.

Partially SupportedIf individuals are thriving with plants in their diet, their diet should not be changed.

Partially SupportedThe atherogenicity of LDL is a more critical question than the mechanisms causing elevated LDL.

Partially SupportedThe liver functions as an enzymatic factory that biotransforms compounds for excretion, rather than storing toxins.

Partially SupportedSunlight exposure can positively affect the gut microbiome and increase microbial diversity.

Partially SupportedHunter-gatherer populations have healthspans that significantly exceed those of modern populations.

Not SupportedSome sunscreens and moisturizers contain high linoleic acid seed oils.

Partially SupportedLiver is a nutrient-dense organ due to its high enzymatic activity and nutrient requirements for biotransformation and excretion functions.

Partially SupportedAvoiding excess linoleic acid in both diet and skincare products is recommended for healthy skin and to avoid photoaging.

Partially SupportedFructose consumed in fruit is unlikely to be detrimental to human health given its long history in the human diet.

Partially SupportedFollowing the speaker's diet recommendations resolved an esophageal spasm issue within five days.

Not SupportedConsuming very large amounts of liver (e.g., 6-10 ounces daily) long-term is not considered beneficial or evolutionarily consistent for humans.

Partially SupportedThe liver biotransforms toxins into excretable forms via phase one and phase two detoxification, rather than acting as a filter.

Partially SupportedIndividuals can experience a noticeable physical sensation from organ meat supplements if their diet lacks organ meats.

Partially SupportedSome individuals may not need skin products if they eat well and consume sufficient animal fats.

Partially SupportedA diet very low in linoleic acid is recommended to maintain skin resilience and health long-term.

Partially SupportedOxalates in the gut can alter the gut microbiome, leading to a decrease in oxalate-eating bacteria and promoting acidosis.

Partially SupportedAdequate intake of animal fats may eliminate the need for skin lotion.

Partially SupportedHumans have historically sought out meat, organs, and saturated fat, suggesting these are evolutionarily appropriate and likely not detrimental.

Partially SupportedIf an individual is thriving, they should not change their current health or lifestyle practices.

Partially SupportedRigorous experiments, such as a complete vegan or carnivorous/animal-based diet without deviations, are needed to obtain reliable data on dietary impacts.

Partially SupportedThe liver is a highly nutritious organ due to its enzymatic activity in biotransformation and detoxification.

Partially SupportedInterventional studies show that meat and organs are beneficial for humans, do not cause inflammation, DNA damage, or immune system activation, and are nourishing.

Partially SupportedGenetic predisposition may influence the need for skin hydration products.

Partially SupportedChapstick can be addictive.

Partially SupportedMuscle twitches can be related to stress, poor sleep, or inadequate electrolytes, potentially due to insufficient carbohydrates.

Partially SupportedPersistent elevated oxidized LDL and Lp(a) suggest an underlying issue beyond diet alone, especially when fasting insulin and full history are unknown in a patient with a blocked left main artery despite a ketogenic diet.

Partially SupportedPersistent oxidized LDL and LP(a) may suggest underlying issues beyond diet, especially in the context of pre-existing coronary artery disease.

Not SupportedSunlight does not age the skin if the diet is appropriate, and humans generally do not need sunscreen.

Partially SupportedAdequate carbohydrate and salt intake, prioritized sleep, and stress management can address muscle twitches.

Partially SupportedTallow can be used as a skincare product without causing an unpleasant odor.

Partially SupportedConsuming sufficient meat, organs, or connective tissue may be important for most humans.

Partially SupportedThe question of how humans can eat to optimize health is a continuous area of exploration and refinement.

Partially SupportedPlant foods and vegetables may harm the gut microbiome.

Partially SupportedReducing vegetable intake and adopting an animal-based or carnivorish diet can increase quality of life.

Partially SupportedAn animal-based or ketogenic diet can be used to reverse coronary artery disease and visceral fat accumulation.

Partially SupportedMelanin protects skin from sun damage, and diet can help fair-skinned individuals adapt to sun exposure.

Partially SupportedPaul Saladino plans to release skincare products, including a sunscreen with linoleic acid, in 2022.

Partially SupportedConsuming excessive amounts of meat and organs is difficult, and the body will signal satiety, indicating that most people are not consuming enough of these nutrient-rich foods.

Partially SupportedGrounding, spending time in nature, playing in community, and sunlight exposure are beneficial.

Partially SupportedBecoming metabolically healthy by improving fasting insulin and eliminating seed oils and processed sugars is the goal for preventing or managing coronary artery disease.

Partially SupportedRed meat, organs, fruit, honey, and raw dairy do not worsen atherosclerosis or metabolic health.

Not SupportedConsuming less nutritious foods like hummus, which contains lectins, phytic acid, and seed oils, can displace more nutrient-dense foods like meat and organs, leading to reduced hunger for them.

Not SupportedTraditional nutritional advice, such as vegetables being good and meat being bad, should be challenged.

Partially SupportedPoor body composition, mood, libido, sleep, emotional stability, depression, anxiety, autoimmune disease, or skin issues warrant questioning one's diet.

Not SupportedThe net benefit of plant foods in one's diet is questionable if other health practices like sun exposure, hormesis, exercise, and consumption of nutrient-dense animal foods are already being optimized.

Partially SupportedAn animal-based diet including organs, meat, fruit, honey, and possibly raw dairy may help improve plaque psoriasis.

Partially SupportedExercise alone does not reverse the negative effects of a poor diet; insulin sensitivity in hunter-gatherers is primarily due to diet, not activity levels.