Andrew Huberman· PhD
contrary to ketamine, which only on average lasts about a week and a half for a single infusion, so it's a much shorter.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
contrary to ketamine, which only on average lasts about a week and a half for a single infusion, so it's a much shorter.
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but what was really interesting about this study and others like it is that the patients experienced relief from their depression almost immediately after taking the drug So within minutes to hours and that it persisted for several days after taking the ketamine
it turned out that when clinicians tried ketamine in depressed patients as a means to relieve depression it had remarkable effects
this is one of the things that makes ketamine an incredibly attractive drug for the treatment of depression especially depression that hasn't responded to other forms of treatment which is that people get relief very very quickly indeed the same day that they initiate the treatment
even after the three weeks of taking ketamine twice per week people often will experience weeks or months of relief from depression when they're not doing the weekly ketamine therapy sessions so that longer term relief that I'm referring to as durability of the treatment is very likely to be the consequence of actual neural circuit rewiring
ketamine elevates mood and for a couple of days after a ketamine trip your mood is definitely improved and now there have been about 30 studies showing that ketamine can um have have a value particularly if you add it on to other treatments of depression which have not been very successful
i mean certainly the unlabeled ketamine which is this bravado this is the johnson version of ketamine which is intranasal and that's indicated you know for a repeated dosing so you start out twice weekly i think it's for a month and then move to weekly um and what they're finding with the long-term studies is that people are staying on the dose i think there was an idea that people might you know progress off or drop down to i think they drop down to fortnightly um but they're staying on it for a number of years now i think um is the kind of long-term data so it is a maintenance