The psychological experience of ketamine was identical in trials where its antidepressant effect was observed.

“But what's interesting there with the ketamine trial is that we didn't see any effect on the dissociation. And so the dissociation was the same each time. So the psychological effect of what we call the trip or the kind of dissociative effect where people are having a psychological phenomenon from ketamine, that was identical both times. And so it kind of, it also challenged this idea that the psychological experience of the psychedelic effect may be all that's necessary to produce an effect and that the pharmacology doesn't matter as long as you can achieve that state.”