A triple therapy involving phase shifting, sleep deprivation, and bright light exposure can retrain the circadian rhythm and has durable antidepressant effects.

“So the idea is that you needed to do some sort of circadian reset. And that part of what depression is, is that it's a dysregulated circadian system. And so mentors of mine say, if you can just get the sleep better, that's half the battle of dealing with depression. 'Cause so many people have insomnia around depression and have a whole host of types of insomnia. Having a hard time falling asleep, waking up in the middle of the night, and waking up earlier, all symptoms of depression. And so what this does is it sleep deprives the individual and then there's a certain calculation of shifting their phase and simultaneously exposing them to bright lights. So that's the triple, the phase shift, the sleep deprivation, and the bright light, to try to get their circadian rhythm. Essentially the theory is reintrained. And so, you know, in the trials that we've done and other trials prior to ours and after, you know, it looked like there was a pretty profound antidepressant effect from this triple therapy that seemed to be durable”