David Sinclair· PhD
How epigenetic changes may contribute to aging by releasing jumping genes (transposons) that break DNA while reinserting into the genome, causing further epigenetic changes
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
How epigenetic changes may contribute to aging by releasing jumping genes (transposons) that break DNA while reinserting into the genome, causing further epigenetic changes
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Suppression of jumping genes i.e. retrotransposons (TE) with drugs is proposed to restore the epigenenome
so there's now some very exciting results that show that some transposons become active and older tissues you know and so i've seen some preliminary data where people said this was associated with increased epigenetic aging