David Sinclair· PhD
Epigenetic clocks predict biological age using DNA methylation patterns, and there are now four generations of them
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Epigenetic clocks predict biological age using DNA methylation patterns, and there are now four generations of them
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
so so the epigenetic clock refers to typically chemical marks on dna that regulate gene expression whether or not you know the gene that is located at specific points in your genome gets turned on or or off and what has been observed is that those marks change with age in pretty much every organism where it's been studied and that you can identify patterns of change at specific locations in the genome so specific changes in these chemical marks with age that correlate very uh strongly with chronological age
mostly when people talk about epigenetic clocks which they're what they're specifically talking about are chemical modifications either to the dna or to the histones that pack the dna and these chemical modifications control gene expressions so things like methylation and acetylation
And and Steve used to go around saying my correlation coefficient is 99. And I was like well that's because that's what you built it on.