David Sinclair· PhD
What happens when a cell is overstressed, overbroke, and overdamaged is that the sirtuins have two jobs. They have to create these bundles of DNA and make sure the cell has its identity, so the genes are read like a proper compact disc or a software in a computer. But when chromosomes break or you crush a cell, there's a panic attack. And the sirtuins rush away to help with that stress and repair the broken DNA. But then they have to find their way back to where they came from and reestablish that structure of the epigenome. And they do a pretty good job. 99.9% of all of those structures go back to how they were. But that .1% never goes back, and over time accumulates. And these are the scratches that cause aging.