The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Now, of course, the challenge is that, you know, that reprogramming is full in the sense that everything is going to be erased. If the reprogramming is done properly, directly all the methylation, so all these methyl groups that you put across DNA that accumulate with age, are going to be removed. All the signatures are essentially removed, so the cell is truly rejuvenated, as like in the beginning.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
if you take a differentiated cell and treat it with a set of transcription factors called the yamanaka factors you can reset the cell back to a pluripotent stem cell and the methylation goes away too
what those factors do is they basically wipe clean the epigenetic changes that have happened over time and also what's amazing is that they restore those cells back to uh if you take it far enough back to a pluripotent state
so there have been these factors called the yamanaka factors that can um reprogram the epig genome so this has been done in cells so if you take cells in culture in a laboratory and you passage them many many times you can see changes in the epigenome just like you might see changes in the epigenome in an animal in tissues and you can put these reprogramming factors into the cells and turn them on
You actually reset the epigenome, and that's how it works.
you know like four transcription factors i think even less now but yeah it's the original from shinya yaminaka um for transcription factors and make this into like a pluripotent stem cell that can become any type of cell in the body the epigenome what happens to the epigenetic you completely reset it i mean to a young completely completely young