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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What are epigenetic clocks used for? | Matt Kaeberlein and Peter Attia — Whalespan

Content›Video›What are epigenetic clocks u…

What are epigenetic clocks used for? | Matt Kaeberlein and Peter Attia

Peter Attia11m · 2025-01-21

Claims Made

10

Claims Supported

5

Support Rate

50%

Support rate

5 of 10 claims supported

5 supported5 partial / not

Claims from this content

6

✓Well SupportedAging involves the disruption of epigenetic patterns, leading to incorrect gene expression and cellular dysfunction.✓Well SupportedYamanaka factors can reprogram the epigenome and restore cells to a pluripotent state.✓Well SupportedReprogramming factors can extend lifespan by 40-50% in progeroid mouse models.✕Not SupportedA claim that an epigenetic change is responsible for aging has not yet grappled with the detailed complexities of the issue.◐Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Yamanaka factors indirectly affect the epigenome, and translating this into an epigenetic programming protocol could offer more control over cell reprogramming.

◐Partially SupportedEpigenetic clocks can be used as a chronological measure of age.