The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And then the scratches are the disruption of that. So genes that were once silent and you could say, it's a gene that is involved in skin. It's starting to come on in the brain, shouldn't be there, but we see this happen and vice versa, the gene might get shut off over time during aging.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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But over time, aging is the equivalent of scratching, the CD and the DVD so that you, you're not playing the right songs and cells when they don't hear the right songs, they get messed up and they don't function well. And that is what I'm saying is the main driver of aging.
And then the scratches are the disruption of that, so genes that were once silent, and you could say it's a gene that is involved in skin, it's starting to come on in the brain, shouldn't be there but we see this happen, and vice versa, the gene might get shut off over time during aging.
our DNA is the hardware, while the epigenome—the chemical tags that turn genes on or off—acts as software. Over time, this software may become maladaptive, driving aging rather than merely reacting to damage.
The aging field is embracing the idea that changes to these methyl patterns and other gene regulators are a part of the aging process, and that it can be reversed.
so the idea is you're getting things turned on and turned off inappropriately as we get older there's a loss of regulation which probably contributes to a loss of homeostasis
what these epigenetic changes the methyl groups that you were talking about do primarily we think um is affect uh uh expression of the genes so basically what you're seeing with aging we think is a shift in the epigenome that leads to certain genes being expressed that shouldn't be and certain genes not being expressed that should be
Well, it turns out it isn't your genes, it's which genes are on and which genes are off, it's the regulation of your genes which we call the epigenome from the Greek word for above, you know, the regulation above the genome.