David Sinclair· PhD
We recognize the pioneering work of Alex Ocampo @ Juan Carlos Belmonte who, in 2016, showed that by switching Yamanaka factors on for short bursts made short-lived mice healthier and longer-lived.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
We recognize the pioneering work of Alex Ocampo @ Juan Carlos Belmonte who, in 2016, showed that by switching Yamanaka factors on for short bursts made short-lived mice healthier and longer-lived.
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In 2016, his group demonstrated that transient expression of the Yamanaka factors could reverse multiple features of aging and extend lifespan in a mouse model of progeria (Ocampo et al., Cell, 2016).
we have this manuscript that says that if we turn on a few key genes in the body of a mouse or in a cell it will quite literally not just act younger and turn on young patterns of genes when you measure its age by Counting these methyl groups where they are it is young again
these reprogramming factors can you know extend lifespan by i don't remember what the exact numbers are but a significant amount maybe 40 50 50
these reprogramming factors can you know extend lifespan by I don't remember what the exact numbers are but a significant amount maybe 40 50 50% which seems like a lot except you have to recognize these mice live you know maybe 25% of the length of a normal Mouse right so they're sick so but but there are impressive changes that happen that that are consistent with the idea that you fixed or made something better
the older one, the first one, 2016 or something, cell paper, I remember they showed, in multiple different organs, it seemed to reverse some of the hallmarks of aging, you know, and the organs were performing functionally a little bit, you know, younger than you would imagine, at least in this premature aging mouse model, and I think even health span of this mouse model that's prematurely aging, it seemed to be improved.