We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
Wait a minute, we were driving up the risk of uterine cancer. And the reason for that is if you just give estrogen with no progesterone to antagonize it, you will thicken the endometrium endlessly and you will increase the risk of hyperplasia. Well, you'll definitely undergo hyperplasia, and then ultimately dysplasia.
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And the reason for that is if you just give estrogen with no progesterone to antagonize it, you will thicken the endometrium endlessly and you will increase the risk of hyperplasia. Well, you'll definitely undergo hyperplasia, and then ultimately dysplasia. Dysplasia is precancerous, and ultimately we were seeing that.
you can't have unopposed estrogen without reaching the risk of endometrial cancer and so that's why we need to have some progestin
as you mentioned estrogen alone does increase the risk of uterine cancer as much by as fivefold
if you just give estrogen with no progesterone to antagonize it you will thicken the endometrium endlessly and you will increase the risk of hyperplasia well you'll you'll definitely undergo hyperplasia and then ultimately dysplasia dysplasia is pre-cancerous and ultimately we were seeing that
women who have an intact uterus take estrogen alone they have a very high risk of developing endometrial cancer and early on they will just have proliferation of the lining of the uterus and increased vaginal bleeding related to taking estrogen without the progestogen