Andrew Huberman· PhD
So that particular enzyme is temperature-sensitive. So when the muscle temperature gets above 39 or 39.5, it shuts off. And that essentially shuts off the fuel supply to the mitochondria.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So that particular enzyme is temperature-sensitive. So when the muscle temperature gets above 39 or 39.5, it shuts off. And that essentially shuts off the fuel supply to the mitochondria.
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ATP is involved in the process of generating muscle contractions. The range of temperatures within which ATP can function and muscles can contract is very narrow. Somewhere around 39 or 40 degrees Celsius, it drops off and you will not be able to generate more contractions.
When muscle heats up, enzymes start getting disrupted, and ATP and muscles can't work so well and those muscles can't contract. The enzyme that's involved here is something called pyruvate kinase. And pyruvate kinase is essentially a rate-limiting step. It's a critical step that you can't bypass if you want muscles to contract. And it's very temperature-sensitive.
So that particular enzyme is temperature sensitive. So when the muscle temperature gets above 39 or 395, it shuts off and that essentially shuts off the fuel supply to the mitochondria that's when you cannot do one more rep.