of ever you've gone out on a long run and at some point in that run you feel like you're aching and your joints hurt or maybe you have shin splints and you push through that part of the reason that you experience a lack of pain at some point usually or you experience a euphoria during or after that exercise is the exercise induced effects on endorphin release or rather to be more specific I should say the exercise induced consequences on the stress system which in turn trigger the release of endorphin.