Andrew Huberman· PhD
And the phytosterols give us an indication of how active that transporter is. So the higher your phytosterols, the more likely you are to respond to ezetimibe.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And the phytosterols give us an indication of how active that transporter is. So the higher your phytosterols, the more likely you are to respond to ezetimibe.
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the only times we see really Head Over Heels responses are in patients who have defective ATP binding cassettes in their gut and we measure that by looking at phytosterol levels so we measure two things one is called cytol one is called compol those are phytosterols so these are cholesterol we don't make it's zerol uh pardon me it's it's it's phytosterol not zerol and so when we measure those levels we know that it speaks to how much plant stero is being absorbed and not being excreted and so when patients have really really high levels of phytosterols you know they have a defective ATP binding cassette and those patients respond really well to aomi it's it's like a Blockbuster in those people