Andrew Huberman· PhD
when we fast, we actually digest certain components within our dietary tract. It actually depletes a good amount of the gut microbiome.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
when we fast, we actually digest certain components within our dietary tract. It actually depletes a good amount of the gut microbiome.
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And so it was surprising to me, but nonetheless interesting that fasting may actually cause a disruption to certain healthy elements of the gut microbiome. But again, there's a caveat. The caveat is that when people eat after a period of fast, there may be a compensatory proliferation, meaning an increase in healthy gut microbiota.
Like, when you fast, you start eating away at the unhealthy and healthy microbiota or they aren't fed. And so it's not, across the board, a good thing, necessarily.
So if you're in the process of acquiring a really good microbiota and you know how to do that, then the the flushing everything out is great.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.