In studies where mice were fed continuously versus calorically restricted, two-thirds of the benefit came from calorie reduction and one-third from additional fasting.

“when you do caloric restriction and then at least for months and you are within 12 hours window um that's that is giving the mice the best benefit the optimum benefit and um two three or five or twelve per Mouse doesn't matter at least for longevity”

“so what was interesting was the limit unfair mice of course they live certain number of days and then this caloric restricted mice that never got into Super fasting but kind of eating snacking throughout day and night that also lift 10 percent extra 10 percent longer so that means caloric restriction extended lifespan by 10 percent”

“and if you force them to i mean i say force because if you give a calorically restricted mouse it's food it's going to eat it right away so if you force them to eat little bits throughout the day you lose a portion of that lifespan benefit which is really interesting”

“let's just say that you get a 30 lifespan extension from 30 caloric restriction that the two-thirds of that benefit comes from the calories but one-third of the benefit actually comes from the fact that those mice eat all their food in a short window and are fasted essentially the rest of that 24-hour period”

“they were able to identify that two-thirds of the benefit came from the reduction in calories and a third of it came from the additional fast”