The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
when you do caloric restriction and then at least for months and you are within 12 hours window um that's that is giving the mice the best benefit the optimum benefit and um two three or five or twelve per Mouse doesn't matter at least for longevity
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and then he measured how long the mouse is going to live um and he used um accountments this is a very standard protocol people count how many mice have dying on which day and then examine them to see whether they've died because they there was an accident or they actually there was a natural cause and then they calculate at the end what is the half life so 50 survival because that's on an average that's a good indicator because if there is an outlier that will live for a long time then that can skew so what was interesting was the limit unfair mice of course they live certain number of days and then this caloric restricted mice that never got into Super fasting but kind of eating snacking throughout day and night that also lift 10 percent extra 10 percent longer so that means caloric restriction extended lifespan by 10 percent
so what was interesting was the limit unfair mice of course they live certain number of days and then this caloric restricted mice that never got into Super fasting but kind of eating snacking throughout day and night that also lift 10 percent extra 10 percent longer so that means caloric restriction extended lifespan by 10 percent
let's just say that you get a 30 lifespan extension from 30 caloric restriction that the two-thirds of that benefit comes from the calories but one-third of the benefit actually comes from the fact that those mice eat all their food in a short window and are fasted essentially the rest of that 24-hour period
they were able to identify that two-thirds of the benefit came from the reduction in calories and a third of it came from the additional fast
and if you force them to i mean i say force because if you give a calorically restricted mouse it's food it's going to eat it right away so if you force them to eat little bits throughout the day you lose a portion of that lifespan benefit which is really interesting
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.