David Sinclair· PhD
It is, if you exercise, it's known, and fast, it's known to raise NAD levels.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
It is, if you exercise, it's known, and fast, it's known to raise NAD levels.
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I mean, I think that NAD levels, you can increase them with fasting. So when you fast, as you mentioned, you convert NAD into NADH in the presence of energy because that's basically when you have a substrate like glucose or a fatty acid, that's when you produce NADH. or FADH2. So in the absence of those substrates, then you start to make your NAD starts to build up.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.