it stimulates what's called autophagy, the clearing away, or the body's ability to eat certain dead cells, so called senescent cells
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it stimulates what's called autophagy, the clearing away, or the body's ability to eat certain dead cells, so called senescent cells
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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So intermittent fasting, for example, one of the benefits of intermittent fasting is that your autophagy occurs. Your body is clearing out all these damaged cells. So that would, in theory, if you've got damaged cells . . . so, the problem is with damaged cells, if they don't die, they become senescent. When they're senescent, they sit around and they secrete pro-inflammatory cytokines. So then they damage nearby cells because the inflammatory cytokines.
Which is really, really, really good because those dysfunctional cells, as you call them, they're often senescent, which means they're not dead, they're not alive, they're sitting around and what are they doing? They're secreting inflammatory... Yeah, they're damaging cells in your body. So, if you can do something to get rid of that crap, you better do it. And fasting, intermittent fasting, has been shown to do it.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.