Andrew Huberman· PhD
caloric restriction extends life across the model systems we discussed
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caloric restriction extends life across the model systems we discussed
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So many studies now showing in worms, in mice, in monkeys, and perhaps even in humans that subcaloric intake or inter uh for long periods of time or perhaps intermittent fasting, we can talk about how we define that um can extend life.
Well, it is and the most reliable way to extend lifespan of any animal or even a yeast cell is to restrict its calories.
the animals that were restricted with food lived longer and it was the first time it's ever got experimentally demonstrated albeit by accident
now there were a couple of things that we already quote unquote knew at this time that had to give you some hope obviously there was the vast literature on caloric restriction so almost without exception and there are some very notable exceptions but almost without exception some form of caloric restriction and we could get into all the details of different species and when it's applied during life and to what extent and wild types versus not but there was clearly a path
so almost without exception and there are some very notable exceptions but almost without exception some form of caloric restriction and we could get into all the details of different species and when it's applied during life and to what extent and wild types versus not but there was clearly a path towards extending life with caloric restriction
one thing that seems to be true is at least from the animal literature caloric restriction seems to reproducibly improve lifespan
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.