Andrew Huberman· PhD
And then fasting-mimicking diets can also stimulate this process of mitophagy.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
And then fasting-mimicking diets can also stimulate this process of mitophagy.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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And I think the most powerful signal and tool that we have right now is, in fact, related to diet. It's calorie restriction. That is the oldest, truest, kind of best-proven way to prevent aging in a wide variety of animal species-- fasting and intermittent fasting.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.