David Sinclair· PhD
Fasting makes mitochondria take up more NAD, which boosts metabolism & protects cells from free-radical damage
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Fasting makes mitochondria take up more NAD, which boosts metabolism & protects cells from free-radical damage
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I think that nad levels or you can you can increase them with fasting so when you fast you know as you mentioned you convert nad into NADH in the presence of of energy because that's basically when you have a substrate like glucose or a fatty acid that's when you produce nadh or fadh2 so in the absence of those substrates then you start to meet your nad starts to build up
And then the other thing, this kind of goes back to the mitochondria induced senescence that we talked about a minute ago is that we know that fasting increases NAD levels and so the NAD plus, NADH ratio.
because fasting increases NAD
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One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.