Citrulline was preventive of fructose-induced non-alcoholic fatty liver disease in rats.

“citrulline found in meat non-essential amino acid prevents fructose induced non-alcoholic fatty liver disease and rats clearly something at least in the wrap model and probably in humans is connected with nitric oxide synthase and insulin resistance non-alcoholic fatty liver disease how cool is that again we're back to the nitric oxide story here with regard to insulin resistance”

“citrulline which is an amino acid found primarily in meat and organs and non-essential amino acids things other than valene isovalene leucine were preventive of fructose-induced non-alcoholic fatty liver disease in rats when they were challenged with fructose”

“citrulline and non-essential amino acids prevent fructose-induced non-alcoholic fatty liver disease in rats”

“or we actually give the non-essential amino acids and citrulline which are the precursors for nitric oxide”

“so in rats and mice if we over feed or if we feed with fructose you will see non-alcoholic fatty liver disease also known as nafld but if they supplement these rats with citrulline and non-essential amino acids what they get is an improvement in arginine metabolism”

“read the conclusion here in our rat model citrulline and non-essential amino acids effectively prevented fructose-induced nafld on the basis of literature data and findings we propose the non-essential amino acids may exert their effects specifically on the liver where citrulline presumably acts at both the hepatic and whole body level in part via improved peripheral arginine metabolism connected with nitric oxide”