Controversial Thoughts: Is Fructose something to fear?

PS

Paul Saladino22m · 2021-08-06

Claims Made

38

Claims Supported

33

Support Rate

87%

Support rate

33 of 38 claims supported

33 supported5 partial / not

Claims from this content

32

Well SupportedDiabetics who consumed 175 grams of honey per day for eight weeks lost approximately two kilograms.Well SupportedHoney causes a lower elevation in plasma glucose and triglycerides and lowers CRP compared to dextrose and sucrose.Well SupportedCitrulline was preventive of fructose-induced non-alcoholic fatty liver disease in rats.Well SupportedRaw dark organic honey increases total nitrite concentrations in plasma, saliva, and urine.Well Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects compared to dextrose and sucrose.

Well SupportedAnimal models suggest substituting honey for refined carbohydrates protects rats from hypertriglyceridemic and peroxidative effects of fructose.

Well SupportedConsuming 200-300 grams of fruit and honey daily does not cause insulin resistance in individuals with a fasting insulin of 3 and stable glycemic variability.

Partially SupportedIn obese individuals, body fatness is positively associated with C-reactive protein levels.

Partially SupportedAdding fruit back to the diet resolved electrolyte problems, heart palpitations, sleep disturbances, and declining testosterone that occurred on a strict carnivore diet.

Partially SupportedAn animal-based diet, which allows for a spectrum of plant toxicity, provides more freedom and can help individuals feel better and have a higher quality of life.

Partially SupportedFructose is not a concern when consumed in whole food forms like meat, bananas, or honey.

Not SupportedStudies showing fructose is detrimental often use animal models (rats/mice) with artificially induced conditions (increased de novo lipogenesis, isolated fructose, high doses, hypercaloric loads) and do not reflect the effects of fructose in whole foods like fruit and honey.

Not SupportedStudies showing negative metabolic outcomes with fructose may be misleading due to isolated fructose, excessive amounts, or lack of whole food matrix.

Partially SupportedA nutritional intervention of increased fruit and vegetable intake lowered circulating ceramides, including C24 ceramide, which is a known inhibitor of insulin signaling.

Partially SupportedA study where young adults consumed increased amounts of fruit and vegetables for eight weeks showed decreased waist circumference, systolic blood pressure, circulating cholesterol, and circulating ceramides, suggesting improved inflammatory status.

Partially SupportedHumans convert much less fructose into fat compared to mice.

Partially SupportedDietary carbohydrate or protein intake has no effect on inflammatory markers in overweight subjects.

Partially SupportedA diet rich in 400 grams of fresh blueberries daily for eight weeks decreased serum hsCRP, IL-6, and IL-12 in patients with metabolic syndrome.

Partially SupportedIncorporating some fruit and honey improved well-being for a speaker who found a fully carnivore diet led to electrolyte imbalances.

Partially SupportedConsuming 330 milliliters of bilberry juice daily for four weeks decreased plasma concentrations of CRP, IL-6, and IL-15 in patients at risk of cardiovascular disease.

Partially SupportedThe majority of trials reviewed in a meta-analysis on fruit and vegetable consumption show either no change or improved plasma blood levels of inflammatory markers like CRP.

Partially SupportedIncreased consumption of fruit containing fructose has generally resulted in either no change or improved metabolic consequences and inflammatory markers.

Partially SupportedMeta-analyses of studies including fruit or fruit extracts show no negative effects on inflammation.

Partially SupportedA higher protein diet with more meat can lead to better overall nutrient intake.

Partially SupportedFructose does not cause weight gain when substituted for other carbohydrates in diets providing similar calories.

Partially SupportedIncluding fruit and vegetables in the diet may significantly improve metabolic syndrome.

Partially SupportedConsuming 400 grams of blueberries daily did not increase inflammatory markers in a study.

Partially SupportedReducing fat intake results in a modest but significant reduction in body weight and body fatness, with no significant differences in weight changes or adverse effects on blood lipids observed when concomitant increases in simple or complex carbohydrates occurred.

Partially SupportedConsumption of 250 milliliters of barberry juice twice daily for four weeks decreased levels of TNF-alpha and IL-8 in obese individuals aged 18-25.

Partially SupportedAvoiding seed oils is crucial for metabolic health in diabetics because they can damage adipocytes and lead to the release of non-esterified fatty acids, which are the basis of metabolic dysfunction.

Partially SupportedConsumption of 92 grams of grape powder shows benign effects on inflammatory biomarkers.

Partially SupportedStudies using isolated fructose or poor study designs with hypercaloric ingestion are often cited to advance the hypothesis that fructose is harmful for humans.