The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you are eating fruit or if you are not eating massive amounts of fructose in fruit i would actually not be a fan of any processed fructose and i'll talk about that in a bit as well the small intestine might be protective against this and you might not actually be getting any significant amount of fructose into the liver or causing any of the changes that people are so concerned about
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low doses of fructose are 90 cleared in the small intestine higher doses pass substantially to the liver this reflects saturation of small intestinal fructose clearance
we propose that the small intestine shields of liver from fructose and excessive doses of fructose overwhelm the small intestine spilling over to the liver where they cause toxicity
there they have a graphic low-dose fructose versus high-dose fructose how much spills over into the liver versus in the portal circulation in the microbiota versus how much is metabolized in the small intestine that is a very interesting mechanism by which the small intestine could absolutely be protecting us and or just metabolizing the fructose as it's supposed to
but we know now that the small intestine is a key piece of this as well
the small intestine could absolutely be um protecting us and or just metabolizing the fructose as it's supposed to right and like i said they use isotopic scrapers isotopic tracers and metabolomics they use mass spec as well
low doses of fructose are 90 cleared in the small intestine higher doses passed substantially to the liver this reflects saturation of small intestinal fructose clearance
based on this we propose that the small intestine shields of liver from fructose and excessive doses of fructose overwhelm the small intestine spilling over to the liver where they cause toxicity
but we know now that the small intestine is a key piece of this as well