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Stop fearing fructose from fruit and honey — Whalespan

Content›Video›Stop fearing fructose from f…

Stop fearing fructose from fruit and honey

Paul Saladino6m · 2022-03-09

Claims Made

14

Claims Supported

12

Support Rate

86%

Support rate

12 of 14 claims supported

12 supported2 partial / not

Claims from this content

11

✓Well SupportedConsuming fructose in low doses from whole fruits may be detoxified by the small intestine before reaching the liver.✓Well SupportedModerate amounts of fructose, up to 1 gram per kilogram of body weight, can be processed without arriving in the liver.✓Well SupportedConsuming fructose in fruit, along with nitric oxide precursors and fiber, may be evolutionarily consistent and beneficial.✓Well SupportedHigh doses of fructose (>1g/kg) overwhelm intestinal absorption and lead to fructose reaching the liver and colonic microbiota.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Fructose enters glycolysis directly below phosphofructokinase, leading to increased lactate or pyruvate and subsequent de novo lipogenesis.

◐Partially SupportedHumans may not require significant amounts of dietary fiber, and obtaining some fiber from fruit is not detrimental.

◐Partially SupportedThe liver is a key site for fructose catabolism, indicated by high expression of ketohexokinase (KHK).

◐Partially SupportedThe rate of intestinal fructose release differs between fiber-rich fruits, juices, and sodas, with fiber-rich fruits offering a more evolutionarily consistent way to consume fructose.

◐Partially SupportedHumans do not necessarily need large amounts of fiber, and moderate amounts of fructose from fruit are likely not harmful.

◐Partially SupportedThe Hadza people do not fear honey and it does not make them insulin resistant.

◐Partially SupportedFiber may be beneficial in the context of fructose consumption by influencing its role in the small intestine.