The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
fructose is it enters glycolysis right below phosphofructokinase which is the rate-limiting enzyme in that whole process so when you take in fructose your processes no matter what your your liver ends up with all this lactate or pyruvate depending on which theory you believe that's got to do something with and that's why it ramps up dnl because it's got to do something with all this end product of glycolysis
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
fructose gets metabolized in the liver via the enzymes there that process doesn't have breaks on it like glucose metabolism does leading to atp consumption when you must phosphorylate fructose with phosphofructokinase you use up atp use up the phosphate group that becomes adp and that adp can accumulate and lead to amp through the action of enzyme systems in the liver
what is interesting to note is that if you are eating fruit or if you're not eating massive amounts of fructose in fruit i would actually not be a fan of any processed fructose and i'll talk about that in a bit as well the small intestine might be protective against this and you might not actually be getting any significant amount of fructose going to the liver or causing any of the changes that people are so concerned about