Fisetin is the most accessible senolytic for individuals interested in trying them, though data is limited.

“mouse study shows FISETIN, a molecule in fruits that kills off senescent cells, dramatically reduces covid symptoms & extends lifespan.”

“Both studies observed that fisetin reduces markers of cellular aging and promotes healthier tissue function. It also appears to encourage the removal of senescent cells that contribute to aging.”

“The polyphenol fisetin found in strawberries clears senescent cells in diabetic mice to prevent aortic aging.”

“Both supplements are promising zombie cell killers in human trials.”

“Both are ALSO Sirt1 activators & extend the lifespan of animals, as Drs. Tatar, Helfand & I reported @Nature”

“Also, check out fisetin, a SIRT1 activator and senolytic:”

“My friend Laura Niedernhofer showed fisetin is senolytic.”

“Plant stress polyphenols fisetin & quercetin have senolytic activity.”

“Right, they are what are called senolytic. Kill senescent cells.”

“So if people are like, man, I really like want to get into senolytics, the gateway right now, the most accessible place for people is fisetin.”

“Couple of colleagues out at the University of Minnesota were able to show that fisetin put in either in the food of the mouse when it's young or even late in life after 700 days, which is like a 75 year old human, was able to extend lifespan quite dramatically, up to 30%, including improving their health.”

“And that's extensively because both it's removing those senescent cells and activating the Sirt-1 defenses.”

“And these have been shown, in the case of fisetin at least, to extend lifespans in some model organisms. - Like fruit flies? - Yeah. - And even in mice recently. I was particularly impressed by the mouse studies. Couple of colleagues out at the University of Minnesota were able to show that fisetin put in either in the food of the mouse when it's young or even late in life after 700 days, which is like a 75 year old human, was able to extend lifespan quite dramatically, up to 30%, including improving their health.”

“There are clinical trials being run out of the Mayo Clinic for fisetin and for quercetin. These are high doses. They're typically two grams taken one day a week for a matter of months.”

“Myself, I'm on a maintenance dose. I take about half a gram of each every day.”

“They do in the dish and in mice and there even some human studies now that show that killing off these senescent cells in the body can improve health. And ultimately, we think, could extend lifespan.”