For individuals with significant health benefits from GLP-1 agonists, the potential unknown risks may be justified.

“my risk/benefit profile does not apply to most people in need of metabolic optimization or weight-loss, for these the benefits of GLP1-RAs probably outweigh the benefits by far, especially that even short to medium term use might bring measurable benefits, especially if accompanied by exercise and improved nutrition.”

“My lens on it is it's a tool in the tool belt. When the tools utilized appropriately and in the right patient population, it can be a tremendous asset, especially in chronically ill, diabetic, morbidly obese people, right?”

“clearly for some people whatever unknown exists around these drugs is worth it right like if you're if an individual you know goes from being 250 lb to 200 lb and having a hemoglobin A1c of 7% to 5.5% that is so positive for them that I think it justifies whatever unknown exists around these drugs”

“oh these modern anorectic drugs are tools to accomplish something and whatever tools you use that make sense for you should be a valid consideration for the goal”