Andrew Huberman· PhD
And there's next gen versions of these that seem to be more long-lasting. So right now, if you look at coming off semaglutide, you're going to see a weight regain.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
And there's next gen versions of these that seem to be more long-lasting. So right now, if you look at coming off semaglutide, you're going to see a weight regain.
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one of the big unknown questions uh when we reviewed this the last time was we just didn't have um real data there was one study that we were able to look at that looked at weight regain after stopping um so you know today we have not just those preliminary studies and insights but we have we have more data on that um I would also just add kind of I I have just as as I'm sure any Doctor Who's prescribed these I have more um anecd toal evidence about kind of what what that what that might look like
we're also going to talk about just a longer Tale on benefits right so you know what do we know about weight loss over a longer period of time um does does does the individual become recalcitrant to the drug at some point in other words you know do they lose weight for 12 months but then all of a sudden they just regain in the presence of the drug still being there there's you know lots of uh types of drugs where that's the case not necessarily for weight loss but where we we sort of get resistant to the effect of the drug um I think today we have a much better understanding of how the drugs promote weight loss so in addition to kind of the clinical studies that look at this I think we have better mechanis IC studies to have more insight into what is actually happening one of the big unknown questions uh when we reviewed this the last time was we just didn't have um real data there was one study that we were able to look at that looked at weight regain after stopping um so you know today we have not just those preliminary studies and insights but we have we have more data on that
that's not true across the board um and it might be the case that over time we're going to learn better and better ways for weight maintenance uh following the the removal of the drug and I think the best case for that might be an individual who's otherwise not exercising um and otherwise doesn't have great eating habits at the outset but who uses the weight loss as a way to Spur those new behaviors
In fact, 70% in the US, 70% of Americans get off the drug at 2 years either because of cost or nausea or whatever, 70% stop taking it. And like you said, when they stop taking it, if habits haven't changed, maybe that's an important caveat, they gain it all back.