Semaglutide was designed to have a longer half-life than native GLP-1, allowing for less frequent injections.

“the reason is it was designed that way it was designed to have a much longer Half-Life so if you're thinking about drug delivery how long the drug stays in circulation is really important so if you could make Native glp-1 but it only stuck around your system for six hours and you had to inject Yourself four times a day that's a much worse trade-off than say being able to have it slightly less potent and just use a more you know greater dose of it but only inject yourself once a week”

“meaning it's replicating as opposed to antagonists you sometimes hear that in Pharmacology antagonists block the effect of a hormone”