Visceral hypersensitivity in the colon may be the biological basis for irritable bowel syndrome and other gut-brain interaction disorders.

“Professor David Julius professor hly in uh jinra at UCSF they have done some beautiful work demonstrating that there are these serotonin releasing cells specifically in the colon they have focus in the colon that they couple two a nerve fibers of the spinal cord and when they are activated now all of a sudden they drive what we call in the clinical uh realm visceral hypers sensitivity so they are responsible for triggering the hypers sensitivity of the nerve fibers the colonic nerve fibers because they detect no noxious stimuli and then ultimately they gate that noxious stimulate and pass it on to the nerve fiber as a in Broad terms as a painful stimulus”