Andrew Huberman· PhD
The hypothalamic neurons that trigger aggression harbor estrogen not testosterone receptors, and yet, respond best to estrogen derived from testosterone.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The hypothalamic neurons that trigger aggression harbor estrogen not testosterone receptors, and yet, respond best to estrogen derived from testosterone.
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it is testosterone converted into estrogen that's activating aggression in the ventromedial hypothalamus, not testosterone itself.
So anytime you hear that testosterone is high, you should think testosterone is high in the body and perhaps estrogen is low in the body. But that means that there's going to be heightened levels of estrogen in the brain and therefore increased propensity for aggression.