Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

Understanding & Controlling Anger & Aggression — Whalespan

Content›Video›Understanding & Controlling …

Understanding & Controlling Anger & Aggression

Andrew Huberman1h 31m · 2022-05-09

Claims Made

121

Claims Supported

108

Support Rate

89%

Support rate

108 of 121 claims supported

108 supported13 partial / not

Claims from this content

74

✓Well SupportedProbiotics in Athletic Greens are vital for microbiotic health, which communicates with the brain and immune system to impact immediate and long-term health.✓Well SupportedHelix Sleep mattresses and pillows are tailored to individual sleep needs assessed through a quiz.✓Well SupportedAthletic Greens is a drink containing vitamins, minerals, probiotics, and adaptogens designed to meet foundational nutritional needs and aid recovery from stress.✓Well SupportedAg One (formerly Athletic Greens) is a vitamin, mineral, and probiotic drink that provides foundational nutritional needs.Well Supported

More from Andrew Huberman

Andrew Huberman on Creatine

Huberman X thread: creatine and aging

Andrew Huberman on Morning Sunlight

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Momentous supplements are offered as a single source for supplements discussed on the Huberman Lab Podcast.

✓Well SupportedSupplementing with 1,000 milligrams of EPA daily can allow individuals requiring prescription antidepressants to use lower doses of those medications.

✓Well SupportedSupplements should be of the highest quality, with ingredient amounts on the label precisely matching the product's content.

✓Well SupportedVitamin K2 is important for calcium regulation and cardiovascular health.

✓Well SupportedVitamin D3 is critical for metabolism, hormone function, and brain function, and most individuals do not get enough even with ample sunlight.

✓Well SupportedTestosterone may enhance the feeling of reward associated with effort.

✓Well SupportedIn female mice, aggression neurons are activated by both male and female intruders equally, whereas in male mice, aggression neurons are only activated by males.

✓Well SupportedL-tyrosine taken at 500-1000mg can increase focus without causing jitteriness or overstimulation.

✓Well SupportedTestosterone amplifies an individual's existing traits, such as sexual arousal, libido, aggressiveness, spontaneous aggression, and reactive aggression.

✓Well SupportedIn maternal female mice, aggression neurons show increased activity compared to virgin females, while mating neurons remain at a consistent activity level.

✓Well SupportedFor many people, 145 milligrams of magnesium threonate is a beneficial dosage for sleep, though some may need slightly more or less.

✓Well SupportedCompetition increases testosterone, which may be an ancient mechanism to encourage more competitive behaviors for resource allocation and reproduction.

✓Well SupportedAfter taking ashwagandha for a maximum of 30 days, a break of at least two to four weeks is recommended to avoid chronically buffering cortisol.

✓Well SupportedMice or humans lacking the aromatase enzyme show reduced aggression despite high testosterone levels, and blocking aromatase prevents testosterone-induced aggression.

✓Well SupportedOmega-3 fatty acid supplementation (1-3g EPA/day) may allow individuals to take lower doses of SSRIs while maintaining mood.

✓Well SupportedA genetic variant affecting estrogen receptor sensitivity can lead to increased aggression, modulated by photoperiod.

✓Well SupportedCaffeine, as a stimulant, causes pupil dilation, indicating high levels of autonomic arousal.

✓Well SupportedIn humans, testosterone can boost status-seeking behaviors, including conspicuous displays of wealth.

✓Well SupportedAcetyl-L-carnitine supplementation was effective in reducing aggressive episodes, impulsivity, and improving self-regulation in children with ADHD.

✓Well SupportedThe periaqueductal gray (PAG) is involved in pain, lordosis response, fear, panic-like behavior, and freezing behavior.

◐Partially SupportedHigh cortisol levels can divert cholesterol away from testosterone and estrogen production towards cortisol synthesis.

◐Partially SupportedEstrogen, not testosterone, activates aggression in the ventromedial hypothalamus.

◐Partially SupportedHigher cortisol levels are associated with increased reactivity and aggression.

◐Partially SupportedThe amygdala has a high concentration of receptors for testosterone.

◐Partially SupportedHot baths of 20-30 minutes can reduce cortisol levels.

◐Partially SupportedL-carnitine is discussed in relation to power output, ATP production, and sperm/egg quality.

◐Partially SupportedThe dosage of acetyl-L-carnitine used in a study for children with ADHD was 100 milligrams per kilogram of body weight, with a maximum of four grams per day.

◐Partially SupportedCaffeine can increase impulsivity by biasing brain and body systems toward action when in a state of increased sympathetic tone.

✓Well SupportedAshwagandha reduces aggression in male and female participants.

◐Partially SupportedDay length is converted into hormonal and chemical signals, including melatonin, dopamine, and stress hormones, which influence brain states.

◐Partially SupportedRegular sauna use can reduce cortisol and improve heart and mental health.

◐Partially SupportedFemales generally have sufficient estrogen to trigger aggression, as they typically produce less testosterone relative to estrogen.

◐Partially SupportedStimulation of the ventromedial hypothalamus (VMH) evokes behavioral aggression and subjective feelings of anger.

◐Partially SupportedHyper-aggression typically involves an interplay between genetics and environment, such as changes in day length.

◐Partially SupportedReactivity is a function of the sympathetic nervous system, activated by adrenaline and cortisol.

◐Partially SupportedShort days are conducive to aggression because they are associated with increased stress hormones and decreased dopamine levels.

◐Partially SupportedTestosterone increases proactivity and willingness to engage in competitive scenarios, not aggressiveness.

◐Partially SupportedHigh cortisol and reduced serotonin increase the likelihood of estrogen triggering aggression.

◐Partially SupportedThe gut microbiome is beneficial for the immune system, brain function, and mood.

✕Not SupportedAggression and grief/mourning use distinct, non-overlapping brain circuits.

◐Partially SupportedIrritability and aggression are distinct states.

◐Partially SupportedUnderstanding the biology and psychology of aggression can improve the understanding of all emotional states.

◐Partially SupportedReducing intake of caffeinated alcoholic beverages may be beneficial for individuals aiming to reduce aggressiveness.

◐Partially SupportedTryptophan-rich diets or tryptophan supplementation can reduce aggressive behavior in children and adults.

◐Partially SupportedSalivary testosterone levels can be a reasonable measure of testosterone if appropriate methods are used.

◐Partially SupportedOptogenetic tools allow for the control of neuronal activity by shining light on specific neurons.

◐Partially SupportedThe ventromedial hypothalamus (VMH) plays a role in aggression and violence seen in psychiatric and developmental disorders.

◐Partially SupportedStimulating a specific brain area in cats caused them to exhibit rage-like behaviors that ceased upon cessation of stimulation.

✕Not SupportedChronic ashwagandha supplementation longer than two weeks can disrupt hormone and neurotransmitter pathways.

◐Partially SupportedHydraulic pressure can describe the buildup of neural signals that drive aggressive behavior or lead to non-reactivity.

◐Partially SupportedHigher salivary testosterone levels in men are associated with more competitive professions.

◐Partially SupportedBrain areas can induce aggressive behavior through electrical stimulation.

◐Partially SupportedAggression is controlled by multiple interacting brain features and variables, not a single area.

◐Partially SupportedSSRIs like fluoxetine or sertraline tend to reduce aggressive behavior.

◐Partially SupportedThe combination of caffeine and alcohol biases individuals towards increased impulsivity and reduced self-regulation.

◐Partially SupportedGetting sunlight in the eyes early and throughout the day is important for regulating cortisol and reducing aggression.

◐Partially SupportedLower serotonin levels shift an individual towards an aggressive tendency.

◐Partially SupportedL-carnitine, omega-3 supplementation, diets favoring tryptophan/serotonin, and hormonal/environmental management can reduce aggressiveness.

◐Partially SupportedPaying attention to sunlight exposure can help understand aggression tendencies.

◐Partially SupportedKonrad Lorenz's work demonstrated that fixed action patterns can be triggered by a single stimulus and involve coordinated neural circuits.

◐Partially SupportedKeeping cortisol low with sufficient sunlight can help offset genetic biases toward certain psychological and behavioral outcomes.

◐Partially SupportedCombining behavioral regimens, attention to time of year, work/school conditions, stress levels, diet, and supplementation can shift an individual's internal state away from aggression and impulsivity.

◐Partially SupportedSerotonin, a neuromodulator associated with well-being, is generally released when well-fed, particularly with carbohydrates.

◐Partially SupportedSupplementation with 1g or more of omega-3 fatty acids daily is common for mood enhancement.

◐Partially SupportedAlcohol initially decreases sympathetic nervous system activity by reducing forebrain inhibition, then acts as a sedative.

◐Partially SupportedConfidence in a drug or supplement's specific mechanism increases when the expected physiological target changes and a corresponding psychological outcome is observed.

◐Partially SupportedOmega-3 fatty acid supplementation has been shown to reduce impulsivity and aggressiveness in certain contexts.

◐Partially SupportedThirty minutes after transdermal testosterone gel application, blood testosterone levels and corticomedial amygdala activation significantly increase.

◐Partially SupportedConsuming caffeinated alcoholic beverages is associated with increased indirect aggression.

◐Partially SupportedCertain synthetic forms of testosterone are known to increase aggressiveness.