Andrew Huberman· PhD
But we can actually say, if you ingest more L-tyrosine there's a high probability that you're going to make more dopamine.
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
But we can actually say, if you ingest more L-tyrosine there's a high probability that you're going to make more dopamine.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
It is a potent stimulus for increasing dopamine. And the timescale for increasing dopamine is about 30 to 45 minutes after ingestion. Dopamine levels start to peak. The classic study that really nailed down the fact that tyrosine has this effect was published way back in 1983, Journal of Clinical Endocrinology and Metabolism that directly compared L-tyrosine supplementation with tryptophan ingestion on plasma dopamine and serotonin.
I've talked before on this podcast about things like L-tyrosine, taking anywhere from 500 to 750 milligrams can increase dopamine because tyrosine is a dopamine precursor, of course.
or in some cases, supplementation with things like L-Tyrosine, which are precursors to dopamine.
things like L-tyrosine for augmenting dopamine
if one wants to increase the amount of dopamine transmission in the brain and body for sake of increasing concentration and focus, one of the most efficient ways to do that is by ingestion of the amino acid L-tyrosine.
There are however, ways to increase dopamine more evenly across the board using nonprescription approaches. And one I already mentioned, which is L-Tyrosine taken typically in dosages of 500 to 1,000 milligrams. L-Tyrosine is not as potent in increasing dopamine as are the prescription drugs that I referred to before. Tends to be milder. For some people it can have a very amplified effect. They feel it right away. It's very intense in elevating focus and motivation and the desire to move. For other people, it's less potent.
similarly 500 milligrams to a thousand milligrams or somewhere in between of something like l-tyrosine which is amino acid precursor to dopamine a different neuromodulator taken a loan or in conjunction with again I believe in separating these things out by product but I suppose you could take Alpha GPC NL tyrosine together if you had already tried them separately and decide they worked well for you then you decide to combine them what people tend to experience is that the cholinergic stimulation from alpha GPC and the dopaminergic stimulation from l-tyrosine or simply l-tyrosine alone or Alpha GPC alone leads to increased levels of focus without the kind of overall feelings of stimulant-based alertness that one would experience with caffeine
there are compounds that are sold over the counter things like amino acids such as l-tyrosine itself that's a very commonly sold and used amino acid
l-tyrosine however has been examined in the scientific literature and at reasonably low dosages has been shown to increase circulating and available levels of dopamine both in the brain and body and lead to increased cognitive performance and in some cases physical output
Many people have turned to the use of elyroine. Elyroine is an amino acid precursor to L-dopa. So, it lies further up the dopamine synthesis pathway. And nowadays, it's very common because elyrocine is sold over the counter in the United States that people will take elyroine as a way to get more energized, alert, and focused. Elyroine is typically taken in capsule form or powder form. Anywhere from 500 to 750 to 1,000 milligs. And the time scale for increasing dopamine is about 30 to 45 minutes after ingestion. Dopamine levels start to peak.