Andrew Huberman· PhD
However, any time you alter your free androgen or free estrogen, particularly one without altering the other, it will alter the binding protein that binds thyroid hormones.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
However, any time you alter your free androgen or free estrogen, particularly one without altering the other, it will alter the binding protein that binds thyroid hormones.
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so when you have excess estrogen or if you're taking X estrogen like a birth control pill it can increase your your sex hormone-binding globulin and your thyroid binding globulin and so that can bind up a lot of your free thyroid hormone that's circulating so thyroid hormone circulates both bound and unbound which is free almost 99% of it is actually bound and then you talk about increasing these binding proteins and your binding up in that last 1% that's circulating so that can have a profound impact on the thyroid